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KMID : 1094720110160050987
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Biotechnology and Bioprocess Engineering
2011 Volume.16 No. 5 p.987 ~ p.987
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Cancer chemopreventive effects of starfish polysaccharide in human breast cancer cells
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Lee Kyu-Shik
Shin Jin-Sun
Nam Kyung-Soo
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Abstract
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We investigated the effect of starfish (Asterina pectinifera) polysaccharide on the progression and metastasis of human breast cancer cells. At a concentration range of 10 ∼ 120 μg/mL the polysaccharide significantly decreased the expression of cyclooxygenase-2 (COX-2) protein induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and of aromatase mRNA. In a wound healing assay, motility of human MDA-MB-231 breast cancer cells was prevented by the polysaccharide in a dose-dependent manner. These results indicate that starfish polysaccharide can prevent breast cancer progression and metastasis by decreasing prostaglandin E2 and estrogen biosynthesis by COX-2 and aromatase, and by inhibiting cell motility. This report presents information regarding the effectiveness of starfish polysaccharide as a chemopreventive agent against breast cancer.
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KEYWORD
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starfish, breast cancer, chemoprevention, polysaccharide, metastasis
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